March 14, 2023

Is Natural Botox Better?

Check out our blog post on natural botox and if it’s better

Botox or botulinum toxin type A has been around for decades smoothing out wrinkles. Botox has been a household name since it was approved by the FDA, but there are other botulinum toxin type A products on the market. How do you choose which one is right for you?

Ok, so there’s botox, dysport, xeomin, and jeuveau. They all contain the same active ingredient, botulinum toxin type A.

How does botulinum toxin type A work?

Botulinum toxin type A is a bacterial endotoxin that causes muscles to become paralyzed. An endotoxin is a toxin present inside a bacterial cell and is released when the cell breaks down. In aesthetics, this endotoxin is used primarily in the forehead, frown lines and around the eyes to help improve the appearance of dynamic wrinkles (wrinkles that are present only when the face is moving) and soften static wrinkles (wrinkles that are present when the face is not moving). When we start using botulinum toxin before static wrinkles develop we can prevent them from occurring.

Botox, dysport, jeuveau and xeomin all smooth out fine lines and wrinkles for younger looking skin for about 3-4 months, on average, until it wears off.

What’s the difference?

For most people, there is no difference between the different botulinum toxin type A products. They all work equally effective and for the same amount of time.

The difference comes in the manufacturers of the products which changes the formulations, cost, and spread of the product. Some feature pure botulinum toxin type A and some have some other proteins in the mix.

The possible side effects for all the toxins are headache, nausea, temporary facial droop, redness and bruising at the site of injection. They all last about 3-4 months until the potency wears off. In rare cases, the toxin may spread leading to trouble breathing, swallowing, and muscle weakness and slurred speech.

The short and sweet of it


Manufacturer is Allergen. Botox is not pure botulinum toxin type A. It is formulated with proteins that may contribute to antibody development over many years of use. Botox also contains human albumin and sodium chloride.


Manufacturerd by Medicis pharmaceutical. Dysport does not have the same molecular weight as botox causing more of a diffusion or spread of the product when injected. It is also formulated with human albumin and contains lactose which makes it contraindicated in patient’s with milk allergy.


Manufactured by Evolus and marketed as “NEWTOX”. Same molecular weight as botox and also contains human albumin and sodium chloride. Jeuveau is newest to the market.


Manufactured by Merz. Xeomin does not contain complexing proteins but does contain human albumin and sucrose. Due to its purified state less product may be needed and resistance is less likely. Xeomin is marketed at “Natural or Naked” botox due to its purified state.

Final thoughts

All products are botulinum type A. All products smooth out fine lines and wrinkles. I am always prone to going more natural and would be inclined to choose the product that contains less “junk” and won’t contributed to resistance later on. Each product is slightly different in the amount of spread so it’s important to go to a practitioner who is experienced in injecting whatever product you choose.

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